90 jobs are at risk as the charity looks to tackle a 30% drop in income.
A continuing wave of redundancies is expected to fuel further demand, says the Association of Charitable Organisations.
Trustees at Islamic Relief Worldwide (IRW) will be vetted by former attorney general Dominic Grieve.
Grants of up to £130,000 are being made available by UCB.
Director of Fundraising and current chair of the Institute of Fundraising Amanda Bringans is among those leaving.
The Charity Commission has appointed an interim manager to the Islamic Research Foundation International as part of its investigation into governance concerns.
A group of 20 cancer charities have linked up for a fundraising campaign to help them tackle the “devastating disruption” of the Covid-19 pandemic.
The charity, which manages six historic sites including the Tower of London, has begun a period of consultation on the proposed redundancies.